Publications
Research
Viswanathan SR, Powers JT, Einhorn W, Hoshida Y, Ng T, Toffanin S, Mermel CH, Lu JL, Lockhart VL, Philips LA, Shah SP, Beroukhim R, Tanwar PS, Azam M, Teixeira J, Meyerson M, Hughes TP, Llovet JM, Radich J, Mullighan CG, Golub TR, Sorensen PHB, Daley GQ. Lin28 Enhances Tumorigenesis and is Associated With Advanced Human Malignancies. Nat Genet. 41:843-8, 2009
Evdokimova V, Tognon C, Ng T, Melnyk N, Fink D, Sorokin A, Ovchinnikov L, Sorensen PH. YB-1 induces an epithelial-to mesenchymal transition in breast cancer cells by translationally activating Snail and other developmental transcription factors. Cancer Cell. 15:402-15. 2009
Davicioni E, Anderson MJ, Finckenstein FG, Lynch JC, Qualman SJ, Shimada H, Schofield DE, Buckley JD, Meyer WH, Sorensen PH, Triche TJ. Molecular classification of rhabdomyosarcoma: genotypic and phenotypic determinants of diagnosis and prognosis. Am J Pathol, 174:550-64, 2009.
Pratscher B, Friedrich C, Goger W, Allen M, Fink D, Thallinger C, Wolscheck M, Frei K, Schofer C, Pehamberger H, Wachek V, Sorensen PH, Muller M, Jansen B, Lucas T. Characterization of NKIP: a novel, Na+/K+-ATPase interacting protein mediates neural differentiation and apoptosis. Exp Cell Res. 1:463-77, 2008
Li Z, Tognon C, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from bipotent alveolar progenitors via activation of AP1 complex. Cancer Cell. 12:542-58, 2007.
Zhang L, Anglesio MS, Zhang F, Yang G, Sarao R, Cronin S, Hara H, Evdokimova V, Nghien M, Arya S, Wada T, Liu PP, Sorensen PH, Penninger JM. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13:1060-1069, 2007.
Ng TL, O’Sullivan MJ, Pallen CJ, Hayes M, Clarkson PW, Winstanley M, Sorensen PH, Nielsen TO, Horsman DE. Ewing Sarcoma with novel translocation t(2;16) producing an in- frame fusion of FUS and FEV. J Mol Diagn. 9:459-63, 2007.
Jin W, Yun C, Martin MJ, Sorensen PHB, Kim SJ. Cellular transformation and activation of the PI3K-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src. Cancer Research 67:3192-3200, 2007.
Kang HG, Zhang J, Jenabi J, Keshelava N, May WA, Reynolds CP, Triche TJ, Sorensen PH. E-cadherin cell-cell adhesion in sarcoma cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Research 67:3094-3105, 2007.
Parham DM, Qualman S, Teot L, Barr FG, Morotti R, Sorensen PH, Triche TJ, Meyer W. Correlation between histology and PAX/FKHR fusion status in alveolar rhabdomyosarcoma: a report from the Children’s Oncology Group. Am J Pathol, 31:895-901, 2007
Huang CC, Cutcliffe C, Coffin CM, Sorensen PH, Beckwith B, Perlman E. Classification of malignant pediatric renal tumors by gene expression. Pediatric Blood and Cancer 46:728-38, 2006
Martin MJ, Melnyk N, Pollard M, Bowden M, Gleave M, Sorensen PHB. The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 26:1754-69, 2006
Evdokimova V, Ruzanov P, Anglesio MS, Zhang F, Ovchinnikov L, Buckley J, Triche TJ, Sorensen PHB. Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Mol Cell Biol 26:277-92, 2006
Lucas T, Pratscher B, Fink D, Wolschek M, Samorapoompichit P, Schofer C, Pehamberger H, Muller M, Sorensen P, Jansen B. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. Stem Cells Dev 14:556-63, 2005
Sorokin AV, Skabkin MA, Guryanov SG, Selutina AA, Nazimov IV, Richard C, Th’ng J, Yau J, Sorensen PHB, Ovchinnikov LP, Evdokimova V. Proteasome-mediated cleavage of the multifunctional protein YB-1 is linked to DNA-damage stress response. EMBO J 24:3602-12, 2005
Jin W, Kim BC, Tognon C, Lee HJ, Pate Sl, Lannon CL, Triche TJ , Sorensen PHB, Kim SJ. The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-b signaling by binding to the TGF-b type II receptor Proc Natl Acad Sci, USA 102:16239-44, 2005
Anglesio MS, Evdokimova V, Melynk N, Zhang L, Fernandez C, Gruday PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, Sorensen PHB. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms’ tumour versus normal kidney. Hum Mol Genet 13:2061-74, 2004
Zhang J, Hu S, Schofield DE, Sorensen PHB, Triche TJ. Selective usage of D-Type cyclins by Ewing’s tumors and rhabdomyosarcomas. Cancer Res 17:6026-34, 2004
Tognon CE, Mackereth CD, Somasiri AM, McIntosh LP, Sorensen PHB. Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Mol Cell Biol 24:4636-50, 2004
Makretsov N, He M, Hayes M, Chia S, Horsman D, Sorensen PHB, Huntsman D. A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretary breast carcinoma. Genes, Chromosomes & Cancer 40:152-157, 2004
Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SK, Sorensen PHB. A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the PTB domain of IRS-1: an essential interaction for transformation. J Biol Chem 279:6225-34, 2004
Diallo R, Tognon C, Knezevich SR, Sorensen PHB, Poremba C. Secretory carcinoma of the breast: a genetically defined carcinoma entity. Verh Dtsch Ges Pathol 193-203, 2003
Diallo R, Schaefer K-L, Ankfalvi A, Decker T, Ruhnke M, Wulfing P, Jackisch C, Luttges J, Sorensen PHB, Singh M, Proremba C. Secretory carcinoma of the breast: a distinct variant of invasive ductal carcinoma assessed by comparative genomic hybridization and immunohistochemistry. Human Pathology 1299–1305, 2003
Nielsen TO, Hsu FD, O’Connell JX, Gilks CB, Sorensen PHB, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Am J Pathol 163: 1449-1456, 2003
McCahon E, Sorensen PHB, Davis JH, Rogers PC, Schultz KR. Non-resectable congenital tumors with the ETV6-NTRK3 gene fusion are highly responsive to chemotherapy. Med Pediatr Onc 40:288-92, 2003
Bayani J, Zielenska M, Paridita A, Al-Romaih K, Karaskova J, Harrison K, Bridge JA, Sorensen PHB, Thorner P, Squire JA. Spectral karyotyping identifies recurrent complex rearrangements of chromosomes 8, 17 and 20 in osteosarcomas. Genes Chromosomes Cancer 36:7-16, 2003
Lestou VS, O’Connell J, Robichaudl M, Salskil C, Mathers J, Maguire J, Chudoba I, Sorensen PHB, Lam W, Horsman DE. Cryptic t(X;18), ins(6;18) and SYT-SSX2 gene fusion in a case of intraneural monophasic synovial sarcoma. Cancer Genetics Cytogenetics, 138:153-156, 2002
Bridge JA, Liu J, Qualman SJ, Suijkerbuijk R, Wenger G, Zhang J, Wan X, Scott Baker K, Sorensen PHB, Barr FG. Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas amplification predominates in embryonal with anaplasia and alveolar subtypes. Genes, Chromosomes & Cancer 33:310-321, 2002
Alessandri AJ, Reid GSD, Bader SA, Massing BG, Sorensen PHB, Schultz KR. ETV6 (TEL)-acute myeloid leukaemia (AML)1 pre-B acute lymphoblastic leukaemia cells are associated with a distinct antigen-presenting phenotype. Brit J Haematology 116:1-7, 2002.
Zielenska M, Bayani J, Pandita A, Toledo S, Marrano P, Andrade J, Thorner P, Sorensen PHB, Squire JA. Comparative genomic hybridization analysis identifies gains of 1p35-36 and chromosome 19 in osteosarcoma. Cancer Genet Cytogenet. 130:14-21, 2001
Sorensen PHB, Mathers J. Reduced sensitivity of paraffin-based RT-PCR assays for ETV6-NTRK3 fusion transcripts in morphologically defined Infantile Fibrosarcoma. Am J Surg Pathol.11:1461-3. 2001
Pierson CR, Schober MS, Wallis T, Sarkar FH, Sorensen PHB, Ebie JN, Srigley JR, Jones EC, Grignon DJ, Adsay V. Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma. Hum Pathol 5:513-20. 2001
Zielenska M, Zhang ZM, Ng K, Marrano P, Bayani J, Ramirez OC, Sorensen PHB, Thorner P, Greenberg M, Squire, JA. Acquisition of secondary structural chromosomal changes in pediatric Ewing’s sarcoma is a probable prognosis factor for tumour response and clinical outcome. Cancer; 91:2156-64.2001
Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, Healy JH, Ueda T, Yoshikawa H, Meloni-Ehrig A, Sorensen PHB, Mertens F, Mandahl N, van der Berghe H, Sciot R, Cin PD, Bridge, J. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene, 20:48-57. 2001
Bridge JA, Weibolt V, Liu J, Baker KS, Perry D, Kruger R, Qualman S, Barr F, Sorensen PHB, Triche T, Suijkerbuijk R. Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an Intergroup Rhabdomyosarcoma study. Genes Chromosomes and Cancer 27:337-344, 2000.
Hahm K-B, Cho Lee KC, Im Y-H, Chang J, Choi S-G, Sorensen PHB, Thiele CJ, Kim S-J. Repression of TGF-b type II receptor gene expression is a major target of the EWS-FLI1 oncogene of Ewing sarcoma. Nature Genetics 23:222-227, 1999.
Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen, PHB. Identification of a novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nature Genetics 18:184-187, 1998
Wilson JL, Masui S, Lim JF, Kalousek D, Horsman D, Sorensen PHB. Cytogenetic and molecular genetic analysis of a pediatric pleomorphic sarcoma reveals similarities to adult malignant fibrous histiocytoma. Cancer Genet Cytogenet 95:141-147, 1997.
Sorensen PHB, Wu JK, Berean KW, Lim JF, Donn W, Frierson HF, Reynolds CP, López-Terrada D, Triche, TJ. Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma. Proc Natl Acad Sci, USA 93:1038-1043, 1996.
Sorensen PHB, Shimada H, Liu XF, Lim JF, Thomas G, and Triche TJ. A subset of sarcomas with myogenic and neural differentiation express the Ewing’s sarcoma EWS/FLI1 fusion gene. Cancer Res 55:1385-1392, 1995.
Sorensen PHB, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. A second Ewing’s Sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nature Genetics 6:146-151, 1994
Sorensen PHB, Chen C-S, Smith FO, Arthur DC, Bernstein ID, Domer PH, Korsmeyer SJ, Hammond GD, Kersey JH. Molecular rearrangements of the MLL gene are present in most cases of infant AML and are strongly correlated with monocytic or myelomonocytic phenotypes. J Clin Invest 93:429-437, 1994.
Reviews
Lessnick SL, Dei Tos AP, Sorensen PHB, Dileo P, Baker LH, Ferrari S, Sundby Hall, K. Small Round Cell Sarcomas. Semin Oncol 36:338-46, 2009
Evdokimova, V, Tognon C, Ng T, Sorensen PHB. Reduced proliferation and enhanced migration: Two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1. Cell Cycle 8:2901-6, 2009
Collini P, Sorensen PHB, Patel S, Blay J-Y, Issels RD, Maki RG, Eriksson M, Garcia del Muro X. Sarcomas with Spindle Cell Morphology. Semin Oncol. 36:324-37, 2009
Evdokimova V, Ovchinnikov LP, and Sorensen PH. Y-box binding protein 1: providing a new angle on translational regulation. Cell Cycle 5:1143-7, 2006
Lannon CL, Sorensen PHB. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Seminars in Cancer Biology 15:215-23, 2005
Syed S, Haque AK, Hawkins HK, Sorensen PHB, Cowan DF. Desmoplastic small round cell tumor of the lung. Arch Pathol Lab Med. 126:1226-8, 2002