If you are interested in pursuing graduate or postdoctoral training in The Department of Molecular Oncology, please send: a cover letter, CV, transcripts, and contact information for 2-3 references to:
CareersMolOnc [at] bccrc [dot] ____________________________________________________________________________________________________________ca
Research Assistant / Technician 4 – Benard Lab
The individual will conduct experiments designed to build new models of receptor expressing tumour cells and reporter gene systems for in vivo imaging by positron emission tomography, fluorescence and bioluminescence systems. This requires expertise in gene transfection techniques, including lentiviral mediated transfection, to introduce new reporter genes and RNA interference. The applicant will also participate in managing the day-to-day operations of a translational research laboratory and may be asked to participate in maintaining tissue cultures, perform biodistribution, imaging and therapy response experiments in rodents and conduct receptor binding assays to support the laboratory.
This position requires a high degree of skills and expertise in molecular biology, protein biochemistry and genetic techniques, as well as autonomy in designing and conducting the experiments. [read more]
Co-op Position – Python Programming for Cancer Genomics Data Analysis Applications
The BC Cancer Agency (BCCA) provides a comprehensive provincial program of cancer control and health care delivery in British Columbia and operates an internationally recognized research program exploring the basic mechanisms and technology development for cancer control, clinical studies and clinical trials, and population health and service research. These research efforts are supported by world-class facilities and platforms in genomics, bioinformatics, molecular pathology, imaging, drug development and tissue banking.
The computational cancer biology team of Dr. Sohrab Shah in the BCCA Department of Molecular Oncology is looking for a co-op student to implement data analysis software for cancer genomics. More specifically, the successful candidate will be working closely with senior programmers and data-analysts on projects that can include:
- Testing and maintenance of existing sequence-analysis pipelines;
- Writing new data analysis pipelines;
- Automation of routine programming and data-analysis tasks. [Read more]
Department of Molecular Oncology
Shah Lab for Computational Biology
British Columbia Cancer Agency/University of British Columbia
Vancouver, BC, Canada
A position is available immediately for a full time bioinformatician in the Shah lab for Computational Cancer Biology. Our group is interested in understanding cancer genomes. We use leading edge DNA sequencing technologies and computational methods to model how cancers evolve, how they acquire mutations and how properties of genomic aberrations drive malignant phenotypes. We continually generate genome-scale datasets from bulk tumor tissue and single cells to address these questions. For optimal interpretation, we have developed numerous robust analytical tools and rigorous computational methods that are applied in different experimental designs from clinical samples to model systems to answer our research questions.
Department of Radiology, University of British Columbia and Department of Molecular Oncology, BC Cancer Agency Research Centre
A post-doctoral position is available to conduct research on the biological evaluation and characterization of new cancer imaging probes within the Functional Cancer Imaging laboratory. The proposed program will include the evaluation of novel peptide and antibody-based radiopharmaceuticals targeting G-coupled receptors and other targets associated with cancer progression and metastasis. The program may also evaluate the potential usefulness of some of the compounds to visualize unstable atherosclerotic plaques. [Read more]
Join a dynamic cancer genomics and computational biology/bioinformatics research team at the BC Cancer Agency, Vancouver, BC CANADA
The following positions are immediately available in the Computational Biology Lab of Dr. Sohrab Shah (compbio.bccrc.ca):
We have an immediate need for a motivated database developer to support data management of big, high dimensional and complex cancer genomics datasets. Focused on next-generation sequencing datasets, the individual will continue the development of robust database solution that has needs for efficient storage and retrieval of human-genome level data from tumour samples. The database developer will interface with a team of software developers, bioinformaticians and principal investigators to ensure enterprise level integrity of genomic data. The position will involve facilitating tight integration of genomic and clinical databases from breast and ovarian cancer research groups. Solutions will be deployed broadly in the BC Cancer Agency. [Read more]
….. to implement algorithms and statistical models for the purposes of analysing high throughput cancer genomics data. The position will entail developing robust, efficient and fault tolerant software in a Linux environment using bioinformatics libraries available in the C++/C, Python and R programming languages. This work will be used to support leading edge research in sequencing cancer genomes and identifying causal mutations in breast and ovarian cancers and lymphomas. The end product(s) will be distributed to computational biology groups worldwide working in the field of cancer genomics. The programmer will interact with other programmers, database developers, bioinformaticians, graduate students, post-doctoral fellows and clinical collaborators in an immersive and dynamic multi-disciplinary research environment. [Read more]
NEW: Post-doctoral researcher (2014SS05)
….. to lead key research projects ongoing in the lab of Dr. Sohrab Shah. The PDF should hold a PhD degree in bioinformatics, computer science, statistics or molecular biology and possess exceptional computational skills. The research will focus on one or more of the following topics, all related to analysis of next generation whole genome sequencing data: i) quantifying and modeling tumour evolution; ii) germline genetics and hereditary cancer; iii) alternative splicing in cancer; iv) the mutational landscape of triple negative breast cancer. The PDF will design and carry out experiments to address key questions in the above topics and lead the writing of scientific manuscripts. Highly motivated individuals with a desire to make an impact in the field of cancer genomics are encouraged to apply.
Post-doctoral fellow in the Biochemistry and Chemical Biology of Spliceosome Regulation
The Genome Sciences Centre Department within the British Columbia Cancer Agency in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin, to study the mechanisms-of-action of pharmacological inhibition of proteins that regulate pre-mRNA splicing. The scientist will join a collaboration with Drs. Samuel Aparicio and Sohrab Shah that is using global genomic technologies to identify changes in alternative splicing due to inhibition of several classes of enzymes that regulate spliceosome function. The objective is to investigate how these enzymes regulate genome-wide spliceosomal function and splice site choice.
The position will perform laboratory research to design and interpret experiments using biochemical, proteomic, molecular and genomic tools to investigate the functional mechanisms of enzyme inhibition on the spliceosome and its regulatory proteins in human cancer cells. The candidate should have experience in ribonucleoprotein biochemistry, mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and RNAi. Experience in the structure/function analysis of RNPs or enzymes and a comprehensive understanding of splicing and spliceosome function are essential.
The successful scientist will join the laboratory of Dr. Gregg Morin in the Michael Smith Genome Sciences Centre at the BC Cancer Agency. In collaboration with the laboratories of Dr. Samuel Aparicio and Dr. Sohrab Shah, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.
The Genome Sciences Centre provides a stimulating working environment and is located at the new British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Additional information can be obtained at www.bcgsc.ca.
Applicants should send a cover letter, curriculum vitae, and names of three referees by email, fax or mail to:
Dr. Gregg B. Morin
Genome Sciences Centre, BC Cancer Agency
675 West 10th Avenue
Vancouver, BC, V6S 1L3, Canada