If you are interested in pursuing graduate or postdoctoral training in The Department of Molecular Oncology, please send: a cover letter, CV, transcripts, and contact information for 2-3 references to:
CareersMolOnc [at] bccrc [dot] ca
Research Associate Position in Molecular Oncology
The Department of Pathology and Laboratory Medicine at the University of British Columbia invites applications for a Research Associate in the field of Molecular Oncology.
The Molecular Oncology and Breast Cancer program which aims to characterize the molecular changes that underpin progression and pathogenesis of cancer is seeking an individual to engage in the investigation of the genomic basis of therapeutic resistance in predictive models of drug action. The successful candidate will work in the laboratory of the Program Director, Dr. Sam Aparicio. http://molonc.bccrc.ca/
Applicants must have a PhD degree and at least 3 years of postdoctoral experience, with relevant knowledge of cancer xenograft models, next generation sequencing technologies and cancer bioinformatics. Responsibilities may include: establishment, propagation and ongoing management of panels of patient-derived xenografts in immunodeficient mice; design and implementation of single agent and combinatorial drug treatment protocols for tumour-bearing mice; coordination of next generation-sequencing and bioinformatic analystic pipelines; design of studies and analytic methodologies to identify mechanisms resistance to specific targeted agents and associated genomic biomarkers; supervision and training of junior researchers; writing and submitting grant applications; writing research abstracts and manuscripts presenting research findings in academic conferences.
UBC and BCCA hire on the basis of merit and are committed to employment equity. UBC is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, persons of any sexual orientation or gender identity, and others who may contribute to the further diversification of ideas.
We encourage all qualified persons to apply; Canadians and permanent residents of Canada will be given priority. Salary will be commensurate with qualifications and experience. The closing date for applications is September 30, 2014, the review of applications will commence immediately. Anticipated start date of the position is November 3, 2014
Interested individuals with a strong post-doctoral level publication track record and a PhD and/or MD and relevant research experience should submit a cv, a statement of research interests and accomplishments as well as contact information for three references, to Jenny Cromarty email@example.com.
Interested candidates should e-mail a letter of application, curriculum vitae, and names of three references to: Kuo-Shyan Lin (firstname.lastname@example.org). Review of applications will begin immediately and will continue until the position is filled.
One postdoc position is immediately available at the Centre of Excellence for Functional Cancer Imaging, BC Cancer Agency in Vancouver, Canada for the development of novel radiotracers for cancer imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT). The postdoc candidate will conduct research in the design and synthesis of imaging probes targeting biomarkers overexpressed in cancers. Research activities will involve the production and isolation of radioisotopes, peptide and multi-step organic synthesis, and radiolabeling small molecules, peptides and antibodies with PET isotopes (C-11, F-18, Sc-44, Cu-61, Cu-64, Ga-68, Y-86, and Zr-89), and SPECT isotopes (Tc-99m, I-123 and In-111).
Qualified candidates should have a PhD degree in organic or medicinal chemistry with experience in peptide or multi-step organic synthesis. Experience with HPLC, micro-scale reactions, and radiochemistry is strongly desirable but not required. The ability to perform research and development in a collaborative environment is required including excellent oral and written communication skills. This joint appointment between BC Cancer Agency and the University of British Columbia (UBC) is for a period of two years with the possibility of renewal.
Join a dynamic cancer genomics and computational biology/bioinformatics research team at the BC Cancer Agency, Vancouver, BC CANADA
The following positions are immediately available in the Computational Biology Lab of Dr. Sohrab Shah (compbio.bccrc.ca):
We have an immediate need for a motivated database developer to support data management of big, high dimensional and complex cancer genomics datasets. Focused on next-generation sequencing datasets, the individual will continue the development of robust database solution that has needs for efficient storage and retrieval of human-genome level data from tumour samples. The database developer will interface with a team of software developers, bioinformaticians and principal investigators to ensure enterprise level integrity of genomic data. The position will involve facilitating tight integration of genomic and clinical databases from breast and ovarian cancer research groups. Solutions will be deployed broadly in the BC Cancer Agency. [Read more]
….. to implement algorithms and statistical models for the purposes of analysing high throughput cancer genomics data. The position will entail developing robust, efficient and fault tolerant software in a Linux environment using bioinformatics libraries available in the C++/C, Python and R programming languages. This work will be used to support leading edge research in sequencing cancer genomes and identifying causal mutations in breast and ovarian cancers and lymphomas. The end product(s) will be distributed to computational biology groups worldwide working in the field of cancer genomics. The programmer will interact with other programmers, database developers, bioinformaticians, graduate students, post-doctoral fellows and clinical collaborators in an immersive and dynamic multi-disciplinary research environment. [Read more]
NEW: Post-doctoral researcher (2014SS05)
….. to lead key research projects ongoing in the lab of Dr. Sohrab Shah. The PDF should hold a PhD degree in bioinformatics, computer science, statistics or molecular biology and possess exceptional computational skills. The research will focus on one or more of the following topics, all related to analysis of next generation whole genome sequencing data: i) quantifying and modeling tumour evolution; ii) germline genetics and hereditary cancer; iii) alternative splicing in cancer; iv) the mutational landscape of triple negative breast cancer. The PDF will design and carry out experiments to address key questions in the above topics and lead the writing of scientific manuscripts. Highly motivated individuals with a desire to make an impact in the field of cancer genomics are encouraged to apply.
Post-doctoral fellow in the Biochemistry and Chemical Biology of Spliceosome Regulation
The Genome Sciences Centre Department within the British Columbia Cancer Agency in Vancouver, British Columbia, Canada has an opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin, to study the mechanisms-of-action of pharmacological inhibition of proteins that regulate pre-mRNA splicing. The scientist will join a collaboration with Drs. Samuel Aparicio and Sohrab Shah that is using global genomic technologies to identify changes in alternative splicing due to inhibition of several classes of enzymes that regulate spliceosome function. The objective is to investigate how these enzymes regulate genome-wide spliceosomal function and splice site choice.
The position will perform laboratory research to design and interpret experiments using biochemical, proteomic, molecular and genomic tools to investigate the functional mechanisms of enzyme inhibition on the spliceosome and its regulatory proteins in human cancer cells. The candidate should have experience in ribonucleoprotein biochemistry, mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and RNAi. Experience in the structure/function analysis of RNPs or enzymes and a comprehensive understanding of splicing and spliceosome function are essential.
The successful scientist will join the laboratory of Dr. Gregg Morin in the Michael Smith Genome Sciences Centre at the BC Cancer Agency. In collaboration with the laboratories of Dr. Samuel Aparicio and Dr. Sohrab Shah, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.
The Genome Sciences Centre provides a stimulating working environment and is located at the new British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Additional information can be obtained at www.bcgsc.ca.
Applicants should send a cover letter, curriculum vitae, and names of three referees by email, fax or mail to:
Dr. Gregg B. Morin
Genome Sciences Centre, BC Cancer Agency
675 West 10th Avenue
Vancouver, BC, V6S 1L3, Canada