- Interpretable dimensionality reduction of single cell transcriptome data with deep generative models.
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
- Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.
- Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
September 25, 2018
Software Developer JOB SUMMARY A full-time position is open immediately for a software developer to work with our interdisciplinary team of researchers and software developers at BC Cancer. The successful applicant will participate in developing, improving and maintaining bioinformatics tools for a high-throughput processing pipeline. We seek candidates with strong Python software engineering and programming […]
May 16, 2016
Roth A, et al. Clonal genotype and population structure inference from single-cell tumor sequencing. Nature Methods. 2016 May 16. doi: 10.1038/nmeth.3867. [Epub ahead of print] Our Nature Methods paper details a new statistical approach for analysing single cell genomics data. The manuscript describes a novel statistical model coupled with a mean field variational inference method […]
May 16, 2016
McPherson A, Roth A, Laks E, Masud T, Bashashati A, Zhang AW, Ha G, Biele J, Yap D, Wan A, Prentice L, Khattra J, Mullaly SC, Kalloger S, Karnezis A, Shumansky K, Siu C, Rosner J, Chan HL, Ho J, Melnyk N, Senz J, Yang W, Moore R, Mungall A, Marra MA, Bouchard-Cote A, Gilks […]
BC Cancer Agency scientists make internationally significant discovery, mapping the evolution of breast cancer ‘avatars’
December 1, 2014
Vancouver – A just-published paper in the prestigious journal Nature highlights how researchers at the BC Cancer Agency are using human breast cancer ‘avatars’ — models of human breast cancers — to measure how complex cancers develop and change over time. The research is unprecedented because it uses single cancer cells to expose how breast […]
April 25, 2013
Press Release from Genome BC Press Release from Genome Canada Dr. Sohrab Shah awarded two grants in the Canadian Institutes of Health Research / Genome Canada 2012 Bioinformatics And Computational Biology Competition: 1. Measuring and modeling tumour evolution from next generation sequencing data: enabling clinical study of clonal diversity in cancer patients 2. Computational interpretation of […]
February 26, 2013
Outsmarting breast cancer, one cell at a time With a $1.25 million grant from the Canadian Cancer Society, Dr Sam Aparicio and his team will answer questions about how breast cancer arises, grows and mutates. The researchers will use sophisticated techniques to analyze DNA from individual breast cancer cells and then observe how the cells […]
January 3, 2013
From BBC.UK: Cancer – when one became 10 Breast cancer cells should be classified into one of 10 different diseases, say researchers. Let’s begin with cancer, because 2012 may be the year that not only changed our understanding of the disease, but showed us where the future of diagnosis and treatment lies. A groundbreaking study […]
October 1, 2012
In North America, breast and ovarian cancers are leading causes of morbidity and mortality in women. Tumours arise through continual accrual of mutations in their genomes. The process by which mutations accrue has a random component, thus individual cells within a tumour can acquire different mutations. This diversity within a tumour results in populations of […]
April 28, 2012
Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments. Researchers have reclassified the disease into 10 completely new categories based on the genetic fingerprint of a tumour. Many of these genes […]
Department of Molecular Oncology study highlights the genetic diversity of triple negative breast cancer
April 5, 2012
A team led by Dr. Sam Aparicio of the Molecular Oncology Department has decoded the genetic make-up of triple negative breast cancer, which could lead to more effective treatment. The study, published online in the international journal Nature, reveals that this form of cancer is not one distinct single entity, but an extremely complex and […]
December 28, 2011
Dr. David Huntsman and colleagues, including Drs. Aparicio, Sorensen and Shah, have identified mutations in a gene called DICER in rare, seemingly unrelated ovarian, uterine, and testicular cancers. When the group began sequencing the genomes of these and other rare tumours, they expected to find different gene mutations in each form of the disease. However, […]
Posted in Aparicio Lab, Media, News And Events, Papers, Shah Lab, Sorensen Lab | Tagged with Aparicio, BCCF, BCCRC, Cancer, CIHR, Genome BC, GSC, Huntsman, Morin, MSFHR, NEJM, Research, Shah, Sorensen, UBC
June 28, 2011
It’s June? How did that happen?! The first half of 2011 has been a busy and exciting time for the Department of Breast and Molecular Oncology; our scientists have published papers, been awarded grants, and travelled all over the world to speak about their work at conferences. As the summer solstice approaches, it seems like […]
October 28, 2009
We have released a C implementation of the software used in Shah et al (2009) Nature: “Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.” Please click here for more information.