Schrader Lab

Schrader

Genomics & Bioinformatics
o Dr Schrader’s research involves assessing the scope and impact of germline findings identified in the course of next generation sequencing in the research and clinical setting. Dr Schrader’s focus is in the use of these technologies in the oncology setting.
• Clinical Genetics, Genetic Counselling and Ethics & Policy
o Dr Schrader’s research involves the molecular diagnosis and characterization of hereditary cancer syndromes in the research and clinical setting with a view to improved surveillance and treatment of associated cancers.

Contact info:

Kasmintan (Intan) Schrader
MBBS, FRCPC, PhD, DABMG
Michael Smith Foundation for Health Research Scholar
Assistant Professor
Department of Medical Genetics
The University of British Columbia
Department of Molecular Oncology
BC Cancer Research Centre
Staff Physician
Hereditary Cancer Program
BC Cancer, part of the Provincial Health Services Authority
Tel: 604.877.6000 x 672198 (Clinical)
Tel: 604.877.6000 x 672324 (Lab)
www.bccancer.bc.ca
Email: ischrader@bccancer.bc.ca

Mailing Address
Box 614-750 West Broadway,
Vancouver, BC, V5Z 1H5
Canada
Fax: 604-707-5931

Academic and professional affiliations:

Michael Smith Foundation for Health Research Scholar
Clinical-Scientist, Canadian Institutes of Health Research
Assistant Professor, Dept of Medical Genetics, The University of British Columbia
Clinician and Scientist, Department of Molecular Oncology, BC Cancer Research Centre
Clinical Geneticist, Hereditary Cancer Program, BC Cancer Agency
Affiliated Investigator, Pancreas Centre BC
Affiliated Investigator, Vancouver Coastal Health Research Institute
Consultant, Memorial Sloan Kettering Cancer Center

Research Areas
• Familial Pancreatic Cancer
• Hereditary Diffuse Gastric Cancer
• Familial Leukemia – defining the genetic basis
• Hereditary susceptibility to cancer – defining the genetic basis
• Multiple primary cancers – defining the genetic basis
• Germline variants in tumor sequencing
• Incidental and secondary germline variants
• Improving diagnosis and management of hereditary cancers

 

Publications (Link to Pubmed)

Select Publications
• K Schrader, K Stratton, R Murali, Y Laitman, L Cavallone, L Offit, Y Wen, N.D. Kauff, M. Robson, Z.K. Stadler,…D.A. Haber, S.M. Lipkin, E. Friedman, W.D. Foulkes, D. Altshuler, J. Vijai, K.Offit.. (2014). Genome sequencing of multiple primary tumors reveals a novel PALB2 variant.. J Clin Oncol..

• Stadler, Z. K. Schrader, K. A. Vijai, J. Robson, M. E. Offit, K.. (2014). Cancer genomics and inherited risk. J Clin Oncol. 32(7)

• Shah, S* Schrader, K. A* Waanders, E* Timms, A. E* Vijai, J* Miething, C* Wechsler, J. Yang, J. Hayes, J. Klein, R. J. Zhang, J. Wei, L. Wu, G. Rusch, M. Nagahawatte, P. Ma, J. Chen, S. C. Song, G. Cheng, J. Meyers, P. Bhojwani, D. Jhanwar, S. Maslak, P. Fleisher, M. Littman, J. Offit, L. Rau-Murthy, R. Fleischut, M. H. Corines, M. Murali, R. Gao, X. Manschreck, C. Kitzing, T. Murty, V. V. Raimondi, S. C. Kuiper, R. P. Simons, A. Schiffman, J. D. Onel, K. Plon, S. E. Wheeler, D. A. Ritter, D. Ziegler, D. S. Tucker, K. Sutton, R. Chenevix-Trench, G. Li, J. Huntsman, D. G. Hansford, S. Senz, J. Walsh, T. Lee, M. Hahn, C. N. Roberts, K. G. King, M. C. Lo, S. M. Levine, R. L. Viale, A. Socci, N. D. Nathanson, K. 
L. Scott, H. S. Daly, M. Lipkin, S. M. Lowe, S. W. Downing, J. R. Altshuler, D. Sandlund, J. T. Horwitz, M. S. Mullighan, C. G. Offit, K. *equal contributions. (2013). A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nature genetics. 45(10)
*First Listed Author

• Ballew, B. J. Joseph, V. De, S. Sarek, G. Vannier, J. B. Stracker, T. Schrader, K. A. Small, T. N. O’Reilly, R. Manschreck, C. Harlan Fleischut, M. M. Zhang, L. Sullivan, J. Stratton, K. Yeager, M. Jacobs, K. Giri, N. Alter, B. P. Boland, J. Burdett, L. Offit, K. Boulton, S. J. Savage, S. A. Petrini, J. H.. (2013). A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet. 9(8)

• Shah, S. Kim, Y. Ostrovnaya, I. Murali, R. Schrader, K. A. Lach, F. P. Sarrel, K. Rau-Murthy, R. Hansen, N. Zhang, L. Kirchhoff, T. Stadler, Z. Robson, M. Vijai, J. Offit, K. Smogorzewska, A.. (2013). Assessment of Mutations in Hereditary Breast Cancers. PLoS One. 8(6)

• Complexo, Southey, M. C. Park, D. J. Nguyen-Dumont, T. Campbell, I. Thompson, E. Trainer, A.
H. Chenevix-Trench, G. Simard, J. Dumont, M. Soucy, P. Thomassen, M. Jonson, L. Pedersen,
I. S. Hansen, T. V. Nevanlinna, H. Khan, S. Sinilnikova, O. Mazoyer, S. Lesueur, F. Damiola, F. Schmutzler, R. Meindl, A. Hahnen, E. Dufault, M. R. Chris Chan, T. Kwong, A. Barkardottir, R. Radice, P. Peterlongo, P. Devilee, P. Hilbers, F. Benitez, J. Kvist, A. Torngren, T. Easton, D. Hunter, D. Lindstrom, S. Kraft, P. Zheng, W. Gao, Y. T. Long, J. Ramus, S. Feng, B. J. Weitzel, J. N. Nathanson, K. Offit, K. Joseph, V. Robson, M. Schrader, K. Wang, S. M. Kim, Y. C. Lynch, H. Snyder, C. Tavtigian, S. Neuhausen, S. Couch, F. J. Goldgar, D. E.. (2013). COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 15(3)

• Goddard, K. A. Whitlock, E. P. Berg, J. S. Williams, M. S. Webber, E. M. Webster, J. A. Lin, J. S. Schrader, K. A. Campos-Outcalt, D. Offit, K. Feigelson, H. S. Hollombe, C.. (2013). Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies. Genet Med. 15(9)

• Alanee, S. Shah, S. Vijai, J. Schrader, K. Hamilton, R. Rau-Murthy, R. Sarrel, K. Manschreck, C. Eastham, J. Offit, K.. (2013). Prevalence of HOXB13 mutation in a population of Ashkenazi Jewish men treated for prostate cancer. Fam Cancer. 12(4)

• Vijai, J. Kirchhoff, T. Schrader, K. A. Brown, J. Dutra-Clarke, A. V. Manschreck, C. Hansen, N. Rau- Murthy, R. Sarrel, K. Przybylo, J. Shah, S. Cheguri, S. Stadler, Z. Zhang, L. Paltiel, O. Ben-Yehuda, D. Viale, A. Portlock, C. Straus, D. Lipkin, S. M. Lacher, M. Robson, M. Klein, R. J. Zelenetz, A. Offit, K.. (2013). Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet. 9(1)

• Alanee, S. Shah, S. Murali, R. Rau-Murthy, R. Schrader, K. A. Offit, K.. (2012). Absence of loss of heterozygosity of BRCA1 in a renal tumor from a BRCA1 germline mutation carrier. Fam Cancer. 12(1)

• Stadler, Z. K. Esposito, D. Shah, S. Vijai, J. Yamrom, B. Levy, D. Lee, Y. H. Kendall, J. Leotta, A. Ronemus, M. Hansen, N. Sarrel, K. Rau-Murthy, R. Schrader, K. Kauff, N. Klein, R. J. Lipkin, S. M. Murali, R. Robson, M. Sheinfeld, J. Feldman, D. Bosl, G. Norton, L. Wigler, M. Offit, K.. (2012). Rare de novo germline copy-number variation in testicular cancer. American journal of human genetics. 91(2)

• Schrader, K. A. Hurlburt, J. Kalloger, S. E. Hansford, S. Young, S. Huntsman, D. G. Gilks, C. B. McAlpine, J. N.. (2012). Germline BRCA1 and BRCA2 mutations in ovarian cancer: utility of a histology- based referral strategy. Obstet Gynecol. 120(2 Pt 1)

• Schrader, K. Offit, K. Stadler, Z. K.. (2012). Genetic testing in gastrointestinal cancers: a case-based approach. Oncology. 26(5)

• Worthley, D. L. Phillips, K. D. Wayte, N. Schrader, K. A. Healey, S. Kaurah, P. Shulkes, A. Grimpen, F. Clouston, A. Moore, D. Cullen, D. Ormonde, D. Mounkley, D. Wen, X. Lindor, N. Carneiro, F. Huntsman, D. G. Chenevix-Trench, G. Suthers, G. K.. (2011). Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut. 61(5)

• Schrader, K. A. Heravi-Moussavi, A. Waters, P. J. Senz, J. Whelan, J. Ha, G. Eydoux, P. Nielsen, T. Gallagher, B. Oloumi, A. Boyd, N. Fernandez, B. A. Young, T. L. Jones, S. J. Hirst, M. Shah, S. P. Marra, M. A. Green, J. Huntsman, D. G.. (2011). Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities. J Pathol. 255(1)

• Schrader, K. A. Masciari, S. Boyd, N. Salamanca, C. Senz, J. Saunders, D. N. Yorida, E. Maines- Bandiera, S. Kaurah, P. Tung, N. Robson, M. E. Ryan, P. D. Olopade, O. I. Domchek, S. M. Ford, J. Isaacs, C. Brown, P. Balmana, J. Razzak, A. R. Miron, P. Coffey, K. Terry, M. B. John, E. M. Andrulis,
I. L. Knight, J. A. O’Malley, F. P. Daly, M. Bender, P. kConFab, Moore, R. Southey, M. C. Hopper, J. L. Garber, J. E. Huntsman, D. G.. (2010). Germline mutations in CDH1 are infrequent in women with early- onset or familial lobular breast cancers. J Med Genet. 48(1)

• Schrader, K. Huntsman, D.. (2010). Hereditary diffuse gastric cancer. Cancer Treat Res. 155

• Schrader, K. A. Gorbatcheva, B. Senz, J. Heravi-Moussavi, A. Melnyk, N. Salamanca, C. Maines- Bandiera, S. Cooke, S. L. Leung, P. Brenton, J. D. Gilks, C. B. Monahan, J. Huntsman, D. G.. (2009). The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors. PLoS One. 4(11)