Schrader Lab

Schrader

Genomics & Bioinformatics
o Dr Schrader’s research involves assessing the scope and impact of germline findings identified in the course of next generation sequencing in the research and clinical setting. Dr Schrader’s focus is in the use of these technologies in the oncology setting.
• Clinical Genetics, Genetic Counselling and Ethics & Policy
o Dr Schrader’s research involves the molecular diagnosis and characterization of hereditary cancer syndromes in the research and clinical setting with a view to improved surveillance and treatment of associated cancers.

Contact info:

Kasmintan (Intan) Schrader
MBBS, FRCPC, PhD, DABMG
Michael Smith Foundation for Health Research Scholar
Assistant Professor
Department of Medical Genetics
The University of British Columbia
Department of Molecular Oncology
BC Cancer Research Centre
Staff Physician
Hereditary Cancer Program
BC Cancer Agency
Tel: 604.877.6000 x 672198 (Clinical)
Tel: 604.877.6000 x 672324 (Lab)
www.bccancer.bc.ca
Email: ischrader@bccancer.bc.ca

Mailing Address
Box 614-750 West Broadway,
Vancouver, BC, V5Z 1H5
Canada
Fax: 604-707-5931

Academic and professional affiliations:

Michael Smith Foundation for Health Research Scholar
Clinical-Scientist, Canadian Institutes of Health Research
Assistant Professor, Dept of Medical Genetics, The University of British Columbia
Clinician and Scientist, Department of Molecular Oncology, BC Cancer Research Centre
Clinical Geneticist, Hereditary Cancer Program, BC Cancer Agency
Affiliated Investigator, Pancreas Centre BC
Affiliated Investigator, Vancouver Coastal Health Research Institute
Consultant, Memorial Sloan Kettering Cancer Center

Research Areas
• Familial Pancreatic Cancer
• Hereditary Diffuse Gastric Cancer
• Familial Leukemia – defining the genetic basis
• Hereditary susceptibility to cancer – defining the genetic basis
• Multiple primary cancers – defining the genetic basis
• Germline variants in tumor sequencing
• Incidental and secondary germline variants
• Improving diagnosis and management of hereditary cancers

Publications:

Peer-reviewed publications for the last year (January – December 2015)

1. Schrader KA, Cheng DT, Joseph V, Prasad M, Walsh M, Zehir A, Ni A, Thomas T, Benayed R, Ashraf A, Lincoln A, Arcila M, Stadler Z, Solit D, Hyman D, Zhang L, Klimstra D, Ladanyi M, Offit K, Berger M, Robson M.(2016). Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA. JAMA Oncol.2(1): 104-111. [epub ahead of print on Nov 10, 2015]

2. Stratton KL, Alanee S, Glogowski EA, Schrader KA, Rau-Murthy R, Klein R, Russo P, Coleman J, Offit K. Outcome of genetic evaluation of patients with kidney cancer referred for suspected hereditary cancer syndromes. Urol Oncol. 2015 Dec 23. pii: S1078-1439(15)00573-6.

3. Laskin J, Jones S, Aparicio S, Chia S, Ch’ng C, Deyell R, Eirew P, Fok A, Gelmon K, Ho C, Huntsman D, Jones M, Kasaian K, Karsan A, Leelakumari S, Li V, Lim H, Ma Y, Mar C, Martin M, Moore R, Mungall A, Mungall K, Pleasance E, Rassekh S, Renouf D, Shen YQ, Schein J, Schrader K, Tinker A, Zhao E, Yip S, Marra M. Lessons learned from the application of whole genome analysis to the treatment of patients with advanced cancers. Cold Spring Harb Mol Case Stud. 2015 Oct 27 1: a000570.

4. Hart SN, Maxwell KN, Thomas T, Ravichandran V, Wubberhorst B, Klein RJ, Schrader K, Szabo C, Weitzel JN, Neuhausen SL, Nathanson K, Offit K, Couch FJ, Vijai J. (2015). Collaborative science in the next generation sequencing era: A viewpoint on how to combine exome sequencing data across sites to identify novel disease susceptibility genes. Brief Bioinform. 2015 Sep 10. pii: bbv075. [Epub ahead of print]

5. Topka S, Vijai J, Walsh MF, Jacobs L, Maria A, Villano D, Gaddam P, Wu G, McGee RB, Quinn E, Inaba H, Hartford C, Pui CH, Pappo A, Edmonson M, Zhang MY, Stepensky P, Steinherz P, Schrader K, Lincoln A, Bussel J, Lipkin SM, Goldgur Y, Harit M, Stadler ZK, Mullighan C, Weintraub M, Shimamura A, Zhang J, Downing JR, Nichols KE, Offit K. (2015). Germline ETV6 Mutations Confer Susceptibility to Acute Lymphoblastic Leukemia and Thrombocytopenia.PLoS Genet.11(6): e1005262.

6. Sullivan J, Kopp R, Stratton K, Manschreck C, Corines M, Rau-Murthy R, Hayes J, Lincon A, Ashraf A, Thomas T, Schrader K, Gallagher D, Hamilton R, Scher H, Lilja H, Scardino P, Eastham J, Offit K, Vijai J, Klein RJ.(2015). An analysis of the association between prostate cancer risk loci, PSA levels, disease aggressiveness and disease-specific mortality.Br J Cancer.1(113): 166-72.

7. Alanee S, Schrader K, Offit K.(2015). Genitourinary Cancers Other than Prostate Cancer in a BRCAtested Cohort from a Single Institution.Eur Urol.67(6): 1196-7.

8. Hansford S, Kaurah P, Li-Chang H, Woo M, Senz J, Pinheiro H, Schrader KA, Schaeffer DF, Shumansky K, Zogopoulos G, Santos TA, Claro I, Carvalho J, Nielsen C, Padilla S, Lum A, Talhouk A, Baker-Lange K, Richardson S, Lewis I, Lindor NM, Pennell E, MacMillan A, Fernandez B, Keller G, Lynch H, Shah SP, Guilford P, Gallinger S, Corso G, Roviello F, Caldas C, Oliveira C, Pharoah PD, Huntsman DG.(2015). Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond.JAMA Oncol.1(1): 23-3.

Other select publications
• K Schrader, K Stratton, R Murali, Y Laitman, L Cavallone, L Offit, Y Wen, N.D. Kauff, M. Robson, Z.K. Stadler,…D.A. Haber, S.M. Lipkin, E. Friedman, W.D. Foulkes, D. Altshuler, J. Vijai, K.Offit.. (2014). Genome sequencing of multiple primary tumors reveals a novel PALB2 variant.. J Clin Oncol..

• Stadler, Z. K. Schrader, K. A. Vijai, J. Robson, M. E. Offit, K.. (2014). Cancer genomics and inherited risk. J Clin Oncol. 32(7)

• Shah, S* Schrader, K. A* Waanders, E* Timms, A. E* Vijai, J* Miething, C* Wechsler, J. Yang, J. Hayes, J. Klein, R. J. Zhang, J. Wei, L. Wu, G. Rusch, M. Nagahawatte, P. Ma, J. Chen, S. C. Song, G. Cheng, J. Meyers, P. Bhojwani, D. Jhanwar, S. Maslak, P. Fleisher, M. Littman, J. Offit, L. Rau-Murthy, R. Fleischut, M. H. Corines, M. Murali, R. Gao, X. Manschreck, C. Kitzing, T. Murty, V. V. Raimondi, S. C. Kuiper, R. P. Simons, A. Schiffman, J. D. Onel, K. Plon, S. E. Wheeler, D. A. Ritter, D. Ziegler, D. S. Tucker, K. Sutton, R. Chenevix-Trench, G. Li, J. Huntsman, D. G. Hansford, S. Senz, J. Walsh, T. Lee, M. Hahn, C. N. Roberts, K. G. King, M. C. Lo, S. M. Levine, R. L. Viale, A. Socci, N. D. Nathanson, K. 
L. Scott, H. S. Daly, M. Lipkin, S. M. Lowe, S. W. Downing, J. R. Altshuler, D. Sandlund, J. T. Horwitz, M. S. Mullighan, C. G. Offit, K. *equal contributions. (2013). A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nature genetics. 45(10)
*First Listed Author

• Ballew, B. J. Joseph, V. De, S. Sarek, G. Vannier, J. B. Stracker, T. Schrader, K. A. Small, T. N. O’Reilly, R. Manschreck, C. Harlan Fleischut, M. M. Zhang, L. Sullivan, J. Stratton, K. Yeager, M. Jacobs, K. Giri, N. Alter, B. P. Boland, J. Burdett, L. Offit, K. Boulton, S. J. Savage, S. A. Petrini, J. H.. (2013). A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome. PLoS Genet. 9(8)

• Shah, S. Kim, Y. Ostrovnaya, I. Murali, R. Schrader, K. A. Lach, F. P. Sarrel, K. Rau-Murthy, R. Hansen, N. Zhang, L. Kirchhoff, T. Stadler, Z. Robson, M. Vijai, J. Offit, K. Smogorzewska, A.. (2013). Assessment of Mutations in Hereditary Breast Cancers. PLoS One. 8(6)

• Complexo, Southey, M. C. Park, D. J. Nguyen-Dumont, T. Campbell, I. Thompson, E. Trainer, A.
H. Chenevix-Trench, G. Simard, J. Dumont, M. Soucy, P. Thomassen, M. Jonson, L. Pedersen,
I. S. Hansen, T. V. Nevanlinna, H. Khan, S. Sinilnikova, O. Mazoyer, S. Lesueur, F. Damiola, F. Schmutzler, R. Meindl, A. Hahnen, E. Dufault, M. R. Chris Chan, T. Kwong, A. Barkardottir, R. Radice, P. Peterlongo, P. Devilee, P. Hilbers, F. Benitez, J. Kvist, A. Torngren, T. Easton, D. Hunter, D. Lindstrom, S. Kraft, P. Zheng, W. Gao, Y. T. Long, J. Ramus, S. Feng, B. J. Weitzel, J. N. Nathanson, K. Offit, K. Joseph, V. Robson, M. Schrader, K. Wang, S. M. Kim, Y. C. Lynch, H. Snyder, C. Tavtigian, S. Neuhausen, S. Couch, F. J. Goldgar, D. E.. (2013). COMPLEXO: identifying the missing heritability of breast cancer via next generation collaboration. Breast Cancer Res. 15(3)

• Goddard, K. A. Whitlock, E. P. Berg, J. S. Williams, M. S. Webber, E. M. Webster, J. A. Lin, J. S. Schrader, K. A. Campos-Outcalt, D. Offit, K. Feigelson, H. S. Hollombe, C.. (2013). Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies. Genet Med. 15(9)

• Alanee, S. Shah, S. Vijai, J. Schrader, K. Hamilton, R. Rau-Murthy, R. Sarrel, K. Manschreck, C. Eastham, J. Offit, K.. (2013). Prevalence of HOXB13 mutation in a population of Ashkenazi Jewish men treated for prostate cancer. Fam Cancer. 12(4)

• Vijai, J. Kirchhoff, T. Schrader, K. A. Brown, J. Dutra-Clarke, A. V. Manschreck, C. Hansen, N. Rau- Murthy, R. Sarrel, K. Przybylo, J. Shah, S. Cheguri, S. Stadler, Z. Zhang, L. Paltiel, O. Ben-Yehuda, D. Viale, A. Portlock, C. Straus, D. Lipkin, S. M. Lacher, M. Robson, M. Klein, R. J. Zelenetz, A. Offit, K.. (2013). Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet. 9(1)

• Alanee, S. Shah, S. Murali, R. Rau-Murthy, R. Schrader, K. A. Offit, K.. (2012). Absence of loss of heterozygosity of BRCA1 in a renal tumor from a BRCA1 germline mutation carrier. Fam Cancer. 12(1)

• Stadler, Z. K. Esposito, D. Shah, S. Vijai, J. Yamrom, B. Levy, D. Lee, Y. H. Kendall, J. Leotta, A. Ronemus, M. Hansen, N. Sarrel, K. Rau-Murthy, R. Schrader, K. Kauff, N. Klein, R. J. Lipkin, S. M. Murali, R. Robson, M. Sheinfeld, J. Feldman, D. Bosl, G. Norton, L. Wigler, M. Offit, K.. (2012). Rare de novo germline copy-number variation in testicular cancer. American journal of human genetics. 91(2)

• Schrader, K. A. Hurlburt, J. Kalloger, S. E. Hansford, S. Young, S. Huntsman, D. G. Gilks, C. B. McAlpine, J. N.. (2012). Germline BRCA1 and BRCA2 mutations in ovarian cancer: utility of a histology- based referral strategy. Obstet Gynecol. 120(2 Pt 1)

• Schrader, K. Offit, K. Stadler, Z. K.. (2012). Genetic testing in gastrointestinal cancers: a case-based approach. Oncology. 26(5)

• Worthley, D. L. Phillips, K. D. Wayte, N. Schrader, K. A. Healey, S. Kaurah, P. Shulkes, A. Grimpen, F. Clouston, A. Moore, D. Cullen, D. Ormonde, D. Mounkley, D. Wen, X. Lindor, N. Carneiro, F. Huntsman, D. G. Chenevix-Trench, G. Suthers, G. K.. (2011). Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): a new autosomal dominant syndrome. Gut. 61(5)

• Schrader, K. A. Heravi-Moussavi, A. Waters, P. J. Senz, J. Whelan, J. Ha, G. Eydoux, P. Nielsen, T. Gallagher, B. Oloumi, A. Boyd, N. Fernandez, B. A. Young, T. L. Jones, S. J. Hirst, M. Shah, S. P. Marra, M. A. Green, J. Huntsman, D. G.. (2011). Using next-generation sequencing for the diagnosis of rare disorders: a family with retinitis pigmentosa and skeletal abnormalities. J Pathol. 255(1)

• Schrader, K. A. Masciari, S. Boyd, N. Salamanca, C. Senz, J. Saunders, D. N. Yorida, E. Maines- Bandiera, S. Kaurah, P. Tung, N. Robson, M. E. Ryan, P. D. Olopade, O. I. Domchek, S. M. Ford, J. Isaacs, C. Brown, P. Balmana, J. Razzak, A. R. Miron, P. Coffey, K. Terry, M. B. John, E. M. Andrulis,
I. L. Knight, J. A. O’Malley, F. P. Daly, M. Bender, P. kConFab, Moore, R. Southey, M. C. Hopper, J. L. Garber, J. E. Huntsman, D. G.. (2010). Germline mutations in CDH1 are infrequent in women with early- onset or familial lobular breast cancers. J Med Genet. 48(1)

• Schrader, K. Huntsman, D.. (2010). Hereditary diffuse gastric cancer. Cancer Treat Res. 155

• Schrader, K. A. Gorbatcheva, B. Senz, J. Heravi-Moussavi, A. Melnyk, N. Salamanca, C. Maines- Bandiera, S. Cooke, S. L. Leung, P. Brenton, J. D. Gilks, C. B. Monahan, J. Huntsman, D. G.. (2009). The specificity of the FOXL2 c.402C>G somatic mutation: a survey of solid tumors. PLoS One. 4(11)