- M.Sc. in Pathology (Excellent degree), Faculty of Medicine, Menoufiya University, Egypt, April 2005.
- M.B.B.Ch. (Excellent degree with Honors), Faculty of Medicine, Menoufiya University, Egypt, December 1999. General rank: The First.
- Aug 2009 – present: PhD student, Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia.
- Sep 2005 – Aug 2009: Assistant Lecturer in Pathology, Faculty of Medicine, Menoufiya University, Egypt.
- Jan 2002 – Sep 2005: Demonstrator in Pathology, Faculty of Medicine, Menoufiya University, Egypt.
- May 2001 – Jul 2002: General Practitioner, Menouf Health Center, Ministery of Health, Egypt.
- Jan 2000 – Feb 2001: House officer, Faculty of Medicine, Menoufiya University Hospital, Egypt.
Sarcomas are a diverse group of malignant neoplasms characterized by early metastatic spread, aggressive behavior, and poor prognosis. Identifying the key genes involved in sarcoma formation and progression is a fundamental issue in cancer research, which may lead to the discovery of novel therapies.
One of the genes believed to play a role in sarcomatogenesis is the Y-box binding protein-1 (YB-1). YB-1 is a member of the highly conserved cold shock domain-containing family of proteins known to bind single and double stranded DNA and single stranded RNA, thereby controlling transcription and translation of a multitude of genes. Our previous studies using a breast cancer model showed that enforced expression of YB-1 promotes an epithelial-mesenchymal transition (EMT) in non-invasive breast epithelial cells, through downregulation of epithelial- and growth-related genes and simultaneous activation of mesenchymal genes. YB-1 induced EMT was accompanied by an enhanced metastatic potential and reduced proliferation rates. In accordance, YB-1 was shown to be upregulated in invasive breast cancer cells and correlated with poor survival. Studies that comprehensively investigate the role of YB-1 in sarcomas development are currently lacking.
Our current research centres around the hypothesis that YB-1 is a major contributor to sarcoma cell motility (migration/invasion) through translational regulation of hypoxia inducible factor-1alpha (HIF-1α), which is known to confer aggressive behavior on solid malignancies. Thus the aggressiveness of sarcoma cells may be attributed to YB-1 and its downstream mediator HIF-1α. We propose that YB-1 may represent a promising future target in the treatment of sarcomas.
· Amal M EL-Naggar, Gabriel Leprivier, Poul H Sorensen. Soft Tissue Sarcomas. In: Cancer Genomics. Elsevier,2014:377-395.
· Gabriel Leprivier, Marc Remke, Barak Rotblat, Adrian Dubuc, Abigail-Rachele F. Mateo, Marcel Kool, Sameer Agnihotri, Amal El-Naggar, Bin Yu, Syam Prakash Somasekharan, Brandon Faubert, Gaëlle Bridon, Cristina E. Tognon, Joan Mathers, Ryan Thomas, Amy Li, Adi Barokas, Mary Bowden, Stephanie Smith, Xiaochong Wu, Andrey Korshunov, Thomas Hielscher, Paul A. Northcott, Jason D. Galpin, Christopher A. Ahern,Ye Wang, Martin G. McCabe, Peter Collins, Russell G. Jones, Michael Pollak, Olivier Delattre, Martin E. Gleave, Eric Jan, Stefan M. Pfister, Christopher G. Proud, W. Brent, Derry, Michael D. Taylor, and Poul H.B. Sorensen. The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation. Cell 153, 1064–1079, May 23, 2013.
· Ariadna Mendoza-Naranjo, Amal El-Naggar, Daniel Wai, Priti Mistry, Nikola Lazic, Fernanda Rocha Rojas Ayala, Isabela Werneck da Cunha, Pablo Rodriguez-Viciana, Hongwei Cheng, Jose Tavares Guerreiro Fregnani, Fernando Soares, Adrienne Flanagan, Patrick Reynolds, Robert Arceci, Timothy Triche, Yuzhuo Wang, Sandra Strauss, and Poul H.B Sorensen. ERBB4 confers metastatic capacity in Ewing sarcoma. EMBO Mol Med. (2013). doi: 10.1002/emmm.201202343
· Chansey J. Veinotte, Dale Corkery, Graham Dellaire, Amal El-Naggar, Kirk Sinclair, Mark L. Bernstein, Poul B. Sorensen, and Jason N. Berman. Abstract 1398: Using zebrafish xenotransplantation to study the role of Y-Box binding protein (YB-1) in the metastasis of Ewing family tumors. Abstract. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1398. doi:1538-7445.AM2012-1398.
· El Naggar, A., Clarkson, P., Zhang, F., Mathers, J., Tognon, C., Sorensen, P. Expression and Stability of Hypoxia Inducible Factor 1α in Osteosarcomas. Pediatr Blood Cancer. 2012 Dec 15;59(7):1215-22. doi: 10.1002/pbc.24191.
· Amin, K., Kandil, M., Asaad, N., EL Naggar, A. Caspase-3 Expression in Hodgkin’s Lymphoma. Journal of Egyptian Society of Pathology 2004:24:1.
SCHOLARSHIPS & AWARDS
- British Columbia Cancer Agency Annual Conference Poster Prize, Nov 2010, Vancouver, Canada.
- University of British Columbia Faculty of Medicine Graduate Award, Sep 2010 – Apr 2011, Vancouver, Canada.
- University of British Columbia Pathology Day Poster Presentation, third place award, May 2010, Vancouver, Canada.
- University of British Columbia Faculty of Medicine Graduate Award, Feb 2010, Vancouver, Canada.
- Graduate Entrance Scholarship, Jan – Apr 2009
- Egyptian Governmental Scholarship, Oct 2008 – Oct 2012
- Mitacs- Accelerate Graduate Research Internship Program, (September 1, 2013 – October 31, 2014, $45,000.00).
- Gold category poster prize for poster presentation, YB-1 CONTRIBUTES TO SARCOMA METASTASIS VIA TRANSLATIONAL ACTIVATION OF HIF1α. Canadian Student Health Research Forum (CSHRF): Winnipeg, Manitoba June 4-6, 2013.