Dr. Samuel Aparicio named co-lead of new Stand Up to Cancer Canada – Canadian Breast Cancer Foundation Dream Team
By: Jenn Currie, Communications Officer, BC Cancer Agency
published on: 10/1/2015
Congratulations to our very own Dr. Samuel Aparicio who was recently named co-lead of the Stand Up to Cancer Canada—Canadian Breast Cancer Foundation Dream Team!
The Dream Team, lead by Dr. Aparicio and Dr. Tak Mak, Princess Margaret Cancer Centre, will research new approaches to the treatment of triple-negative breast cancer (TNBC) and other aggressive types of breast cancer.
With a $9 million investment over four years, Dr. Aparicio and his team will conduct clinical trials in six provinces with the hopes of achieving promising results and getting new treatments to patients quickly. The Dream Team will test three candidate drugs for their effectiveness in halting or slowing the processes by which cancer cells reproduce.
These novel treatments will be aimed at changes in the genomes of cancer cells that make the tumours unstable and vulnerable to attack. The new drugs will exploit the cancer’s “Achilles’ heel,” and the researchers hope to identify biomarkers of drug activity that will help match patients with the most effective treatments for their particular form of breast cancer.
“If our clinical trials are successful, our program has the potential to eventually deliver new drugs that will act against several very aggressive breast cancer subtypes, which currently lack effective targeted therapies,” says Dr. Aparicio. “By exploiting our increased understanding of cancer evolution and genomics to the single-cell level, we hope to co-develop biomarkers and treatment combination strategies that will identify the patient groups most likely to benefit from the new drugs we are testing.”
The Mak-Aparicio team was selected after careful consideration by the Stand Up to Cancer (SU2C) Canada Scientific Advisory Committee (CSAC). The review process began with a Call for Ideas issued by American Association for Cancer Research (AACR) International – Canada in October 2014. Three finalist teams met with the CSAC and the Breast Cancer Subcommittee in Toronto in June 2015 to present their plans and respond to questions.
The project is funded by – Stand Up To Cancer Canada (SU2C Canada), the Canadian Breast Cancer Foundation (CBCF), with support from CIBC and the Ontario Institute for Cancer Research (OICR). The American Association for Cancer Research (AACR) International – Canada, is SU2C Canada’s scientific partner.
Check out this video of the Stand Up to Cancer Canada — Canadian Breast Cancer Foundation Dream Team.