- Interpretable dimensionality reduction of single cell transcriptome data with deep generative models.
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
- Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.
- Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
June 2, 2016
Building on the world’s largest breast cancer study, BC Cancer Agency scientists map the relationship between cancer mutations and clinical outcomes in 2,433 women. Dr. Samuel Aparicio co-led a study with Dr. Carlos Caldas from Cancer Research UK and these teams have shown that what lies beneath the surface is critical as no two breast […]
May 16, 2016
Roth A, et al. Clonal genotype and population structure inference from single-cell tumor sequencing. Nature Methods. 2016 May 16. doi: 10.1038/nmeth.3867. [Epub ahead of print] Our Nature Methods paper details a new statistical approach for analysing single cell genomics data. The manuscript describes a novel statistical model coupled with a mean field variational inference method […]
May 16, 2016
McPherson A, Roth A, Laks E, Masud T, Bashashati A, Zhang AW, Ha G, Biele J, Yap D, Wan A, Prentice L, Khattra J, Mullaly SC, Kalloger S, Karnezis A, Shumansky K, Siu C, Rosner J, Chan HL, Ho J, Melnyk N, Senz J, Yang W, Moore R, Mungall A, Marra MA, Bouchard-Cote A, Gilks […]
April 16, 2013
The inaugural Bust a Move event in Vancouver raised an amazing $500,000 for breast cancer research on April 13, 2013. Thank you to everyone who took part or volunteered! Dr. Sam Aparicio‘s team: Team Aparition Photos from the event: (Thanks to Raewyn Billings for the […]
December 28, 2011
Dr. David Huntsman and colleagues, including Drs. Aparicio, Sorensen and Shah, have identified mutations in a gene called DICER in rare, seemingly unrelated ovarian, uterine, and testicular cancers. When the group began sequencing the genomes of these and other rare tumours, they expected to find different gene mutations in each form of the disease. However, […]
Posted in Aparicio Lab, Media, News And Events, Papers, Shah Lab, Sorensen Lab | Tagged with Aparicio, BCCF, BCCRC, Cancer, CIHR, Genome BC, GSC, Huntsman, Morin, MSFHR, NEJM, Research, Shah, Sorensen, UBC