- Interpretable dimensionality reduction of single cell transcriptome data with deep generative models.
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
- Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.
- Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
BC Cancer Agency scientists make internationally significant discovery, mapping the evolution of breast cancer ‘avatars’
December 1, 2014
Vancouver – A just-published paper in the prestigious journal Nature highlights how researchers at the BC Cancer Agency are using human breast cancer ‘avatars’ — models of human breast cancers — to measure how complex cancers develop and change over time. The research is unprecedented because it uses single cancer cells to expose how breast […]
January 3, 2013
From BBC.UK: Cancer – when one became 10 Breast cancer cells should be classified into one of 10 different diseases, say researchers. Let’s begin with cancer, because 2012 may be the year that not only changed our understanding of the disease, but showed us where the future of diagnosis and treatment lies. A groundbreaking study […]
April 28, 2012
Scientists at the BC Cancer Agency and University of British Columbia have identified new breast cancer genes that could change the way the disease is diagnosed and form the basis of next-generation treatments. Researchers have reclassified the disease into 10 completely new categories based on the genetic fingerprint of a tumour. Many of these genes […]
Department of Molecular Oncology study highlights the genetic diversity of triple negative breast cancer
April 5, 2012
A team led by Dr. Sam Aparicio of the Molecular Oncology Department has decoded the genetic make-up of triple negative breast cancer, which could lead to more effective treatment. The study, published online in the international journal Nature, reveals that this form of cancer is not one distinct single entity, but an extremely complex and […]
Major breast cancer research breakthrough from the Department of Molecular Oncology and the Genome Sciences Centre
October 7, 2009
Dr. Sam Aparicio of the Department of Molecular Oncology, in partnership with Dr. Marco Marra of the Genome Sciences Centre, has published the first complete genome sequence of a breast cancer. The article is featured on the front cover of this weeks issue of Nature, one of the world’s most prestigious science journals. The study […]