- Interpretable dimensionality reduction of single cell transcriptome data with deep generative models.
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
- Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.
- Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
June 2, 2016
Building on the world’s largest breast cancer study, BC Cancer Agency scientists map the relationship between cancer mutations and clinical outcomes in 2,433 women. Dr. Samuel Aparicio co-led a study with Dr. Carlos Caldas from Cancer Research UK and these teams have shown that what lies beneath the surface is critical as no two breast […]
May 16, 2016
Roth A, et al. Clonal genotype and population structure inference from single-cell tumor sequencing. Nature Methods. 2016 May 16. doi: 10.1038/nmeth.3867. [Epub ahead of print] Our Nature Methods paper details a new statistical approach for analysing single cell genomics data. The manuscript describes a novel statistical model coupled with a mean field variational inference method […]
May 16, 2016
McPherson A, Roth A, Laks E, Masud T, Bashashati A, Zhang AW, Ha G, Biele J, Yap D, Wan A, Prentice L, Khattra J, Mullaly SC, Kalloger S, Karnezis A, Shumansky K, Siu C, Rosner J, Chan HL, Ho J, Melnyk N, Senz J, Yang W, Moore R, Mungall A, Marra MA, Bouchard-Cote A, Gilks […]
February 17, 2015
NSERC Brockhouse Prize For CycloMed99 17 February 2015 For their outstanding teamwork in realizing a solution for safe and reliable isotope production for hospitals in Canada, interdisciplinary research team CycloMed99 will be receiving a prestigious national award at a ceremony in Ottawa today. The Honourable David Johnston, Governor General of Canada, will present the NSERC Brockhouse Canada […]
Posted in Benard Lab, Media, News And Events | Tagged with BC Cancer Agency, BCCA, BCCRC, Benard, Brockhouse Prize, Cancer Research, Cyclotron, Francois Benard, Media, Medical Isotopes, NSERC, Radiology, Research, TRIUMF, UBC
April 11, 2013
From the Vancouver Province By Mike Raptis The Province April 7, 2013 A group of Vancouver researchers will be playing a central role in a newly-formed international “pediatric cancer dream team.” The announcement came Sunday during the 2013 annual meeting of the St. Baldrick’s Foundation at the American Association for Cancer Research in Washington, D.C. The […]
February 28, 2012
The American Association for the Advancement of Science (AAAS) 2012 Annual Meeting wrapped up at the Vancouver Convention Centre on Monday. This scientific conference – the biggest of its kind – was a great opportunity for local researchers to shine, and two of our department’s Principal Investigators were among the Vancouver-based scientists invited to speak […]
December 28, 2011
Dr. David Huntsman and colleagues, including Drs. Aparicio, Sorensen and Shah, have identified mutations in a gene called DICER in rare, seemingly unrelated ovarian, uterine, and testicular cancers. When the group began sequencing the genomes of these and other rare tumours, they expected to find different gene mutations in each form of the disease. However, […]
Posted in Aparicio Lab, Media, News And Events, Papers, Shah Lab, Sorensen Lab | Tagged with Aparicio, BCCF, BCCRC, Cancer, CIHR, Genome BC, GSC, Huntsman, Morin, MSFHR, NEJM, Research, Shah, Sorensen, UBC
June 28, 2011
It’s June? How did that happen?! The first half of 2011 has been a busy and exciting time for the Department of Breast and Molecular Oncology; our scientists have published papers, been awarded grants, and travelled all over the world to speak about their work at conferences. As the summer solstice approaches, it seems like […]
New paper: tumor model systems aid in identifying a critical pathway in ETV6-NTRK3 oncogene driven breast cancers
January 28, 2011
Dr. Cristina Tognon, a Research Scientist in Dr. Sorensen’s laboratory, recently published a new paper in the journal Cancer Research on the role of the insulin receptor and related proteins in secretory breast cancer. “ETV6-NTRK3-Mediated Breast Epithelial Cell Transformation is Blocked by Targeting the IGF1R Signaling Pathway” – Tognon CE, Somasiri AM, Evdokimova VE, Trigo […]
BC Cancer Agency and Pfizer Oncology scientists identify the P-cadherin protein as a prognostic biomarker in breast cancer
October 28, 2010
Scientists from the BC Cancer Agency and Pfizer Oncology have published the first results of their three-year research collaboration. The paper, published in the journal Modern Pathology, analyzed the expression of the P-cadherin protein in breast cancer. P-cadherin is involved in controlling the development and function of the normal mammary gland, but may also play […]
November 28, 2009
The world is facing a shortage of the key medical isotope Technetium-99m (Tc-99m). More than 80% of the estimated 1.5 million nuclear medicine procedures performed annually in Canada use radiopharmaceuticals based on this isotope, which is currently produced using nuclear reactors. Together with TRIUMF and other partners, the BC Cancer Agency (BCCA) has received a […]
Major breast cancer research breakthrough from the Department of Molecular Oncology and the Genome Sciences Centre
October 7, 2009
Dr. Sam Aparicio of the Department of Molecular Oncology, in partnership with Dr. Marco Marra of the Genome Sciences Centre, has published the first complete genome sequence of a breast cancer. The article is featured on the front cover of this weeks issue of Nature, one of the world’s most prestigious science journals. The study […]