- Interpretable dimensionality reduction of single cell transcriptome data with deep generative models.
- The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level.
- Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.
- Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
October 1, 2012
In North America, breast and ovarian cancers are leading causes of morbidity and mortality in women. Tumours arise through continual accrual of mutations in their genomes. The process by which mutations accrue has a random component, thus individual cells within a tumour can acquire different mutations. This diversity within a tumour results in populations of […]
Department of Molecular Oncology study highlights the genetic diversity of triple negative breast cancer
April 5, 2012
A team led by Dr. Sam Aparicio of the Molecular Oncology Department has decoded the genetic make-up of triple negative breast cancer, which could lead to more effective treatment. The study, published online in the international journal Nature, reveals that this form of cancer is not one distinct single entity, but an extremely complex and […]